--- title: Dr. Dan’s Guest Appearance on the Optimal Protein Podcast with Vanessa Spina description: Dr. Dan Gubler was a guest on the Optimal Protein Podcast with Vanessa Spina to share insights on optimizing genes with ketosis and intermittent fasting image: https://blog.threeinternational.com/hubfs/Optimal-Protein-Podcast-Featured-Image-v4.jpg --- [ All posts ](https://blog.threeinternational.com/en/all) June 14, 2024 # Dr. Dan’s Guest Appearance on the Optimal Protein Podcast with Vanessa Spina By  [ Three ](https://blog.threeinternational.com/en/author/three)  ·  3 minute read - [![Optimal Protein Podcast with Vanessa Spina Featuring Dr Dan Gubler THREE](https://blog.threeinternational.com/hs-fs/hubfs/Optimal-Protein-Podcast-Featured-Image-v3.jpg?width=1200&height=800&name=Optimal-Protein-Podcast-Featured-Image-v3.jpg) ](https://podcasts.apple.com/us/podcast/epigenetics-how-to-optimize-your-genes-with-ketosis/id1344681226?i=1000655219682) Our Chief Scientific Officer, Dr. Dan Gubler, Ph.D., was recently featured on the popular podcast [***Optimal Protein Podcast (Fast Keto) hosted by Vanessa Spina***](https://blog.threeinternational.com/en/dr.-dan-guest-appearance-on-the-optimal-protein-podcast-with-vanessa-spina?hsLang=en). In the episode titled "[Epigenetics: How To Optimize Your Genes with Ketosis, Intermittent Fasting, Phytonutrients and More!](https://podcasts.apple.com/us/podcast/epigenetics-how-to-optimize-your-genes-with-ketosis/id1344681226?i=1000655219682)" [Dr. Gubler](https://threeinternational.com/en/our-team) shared his extensive knowledge on biochemical processes, organic chemistry, and phytonutrients. Here, we’ll highlight the key points discussed in the podcast and dive into how [Dr. Gubler](https://threeinternational.com/en/our-team)'s work at [THREE](https://threeinternational.com/en) International is redefining the standards of nutritional health. ### Understanding Epigenetics and Its Impact on Health [Dr. Gubler](https://threeinternational.com/en/our-team) began by explaining the concept of epigenetics, which involves the study of how genes are turned on or off and how this regulation affects our health. Unlike genetic testing, which only tells us the propensity for an issue to occur, epigenetics provides real-time insights into whether a gene is expressed or not. Essentially, it's about ensuring that the genes we want activated are indeed turned on by the foods we eat, ketones, and various practices such as grounding and deep breathing. ### The Role of Ketones in Epigenetics One of the fascinating aspects of the discussion was the role of ketones in epigenetics. Ketones are not just fuel for the body; they also play a significant role in gene regulation. [Dr. Gubler](https://threeinternational.com/en/our-team) highlighted that ketones are crucial in support of genes related to insulin, as well as cognitive health. He emphasized that ketones help support the production of Brain-Derived Neurotrophic Factor (BDNF), a protein vital for brain health. ### Intermittent Fasting and Resistance Training Intermittent fasting and resistance training were also discussed as powerful tools for optimizing epigenetics. [Dr. Gubler](https://threeinternational.com/en/our-team) explained that intermittent fasting allows the body to focus on homeostasis and proper gene regulation by reducing the number of biochemical reactions occurring at any given time. This period of rest enables the body to maintain its internal balance and improve overall function. ### Signal Transduction Cascades: The Domino Effect [Dr. Gubler](https://threeinternational.com/en/our-team) provided insights into signal transduction cascades, which are biochemical pathways that lead to the activation of genes. He likened these cascades to a domino effect, where each domino represents a step in the process. Ketones are one of the key molecules involved in these cascades, highlighting their importance in gene support and overall health. ### The Importance of Lifestyle Factors [Dr. Gubler](https://threeinternational.com/en/our-team) emphasized that lifestyle factors such as diet, sleep, exercise, stress management, and environmental factors play a crucial role in epigenetics. Poor lifestyle choices can hinder the body's ability to produce ketones and maintain proper gene support. He recommended practices like intermittent fasting and a balanced diet rich in phytonutrients to support optimal epigenetic function. ### Choosing the Right Supplements [Vanessa Spina](https://podcasts.apple.com/us/podcast/optimal-protein-podcast-fast-keto-with-vanessa-spina/id1344681226) and [Dr. Gubler](https://threeinternational.com/en/our-team) discussed the importance of choosing high-quality supplements that contain essential vitamins, minerals, trace minerals, and phytonutrients. [Dr. Gubler](https://threeinternational.com/en/our-team) stressed the significance of absorption, explaining that even the most powerful molecules are ineffective if they are not absorbed into the cells. He advised selecting supplements with advanced technologies that enhance bioavailability. Learn more about [Vitalité](https://threeinternational.com/en/productdetail/2/2802/US) by THREE, a highly bioavailable Superfood Blend + Daily Multivitamin Complex. ### Caffeine: The Misunderstood Molecule The podcast also touched on caffeine, a widely studied molecule that often receives mixed reviews. [Dr. Gubler](https://threeinternational.com/en/our-team) pointed out that caffeine has several proven benefits, including healthy support of microbiome health. He highlighted that the key to reaping the benefits of caffeine lies in moderation and understanding its effects on the body. ### Listen to the Full Episode To dive deeper into the fascinating discussion on epigenetics, ketones, intermittent fasting, and phytonutrients, listen to the [full episode](https://podcasts.apple.com/us/podcast/epigenetics-how-to-optimize-your-genes-with-ketosis/id1344681226?i=1000655219682) of the [***Optimal Protein Podcast (Fast Keto) with Vanessa Spina featuring Dr. Dan Gubler***](https://podcasts.apple.com/us/podcast/epigenetics-how-to-optimize-your-genes-with-ketosis/id1344681226?i=1000655219682) [here](https://podcasts.apple.com/us/podcast/epigenetics-how-to-optimize-your-genes-with-ketosis/id1344681226?i=1000655219682). [Dr. Dan Gubler](https://threeinternational.com/en/our-team)'s insights on the Optimal Protein Podcast provide a wealth of knowledge on supporting genes through ketosis, intermittent fasting, and phytonutrients. His research and expertise highlight the importance of lifestyle choices and advanced supplement technologies in supporting optimal health. At THREE International, we are proud to have [Dr. Gubler](https://threeinternational.com/en/our-team) leading the way in redefining nutritional health standards. ![Optimal Protein Podcast with Vanessa Spina](https://blog.threeinternational.com/hubfs/Optimal%20Protein%20Podcast%20with%20Vanessa%20Spina.webp) [ Listen Now ](https://podcasts.apple.com/us/podcast/epigenetics-how-to-optimize-your-genes-with-ketosis/id1344681226?i=1000655219682)   ### Dr. Dan Gubler and THREE International At [THREE](https://threeinternational.com/en) International, [Dr. Dan Gubler](https://threeinternational.com/en/our-team) is at the forefront of developing innovative, science-backed supplements that optimize cellular absorption and overall wellness. His work is not just about improving supplements; it’s about redefining the standards of nutritional health. With 16 patents and over 70 nutritional supplements under his belt, [Dr. Gubler](https://threeinternational.com/en/our-team)'s contributions to the field are profound and transformative. ___________________________________________________________________________ ### About THREE™ [THREE](https://threeinternational.com/en)™ has redefined the science of supplementation with cutting-edge cellular absorption technology, ensuring that our products are efficient, effective, and unbeatably bioavailable. Behind our world-leading, advanced delivery products is our scientific community, a team of leaders, led by [Dr. Dan Gubler](https://threeinternational.com/en/our-team), from across the medical field. Our mission is twofold: improve quality of life through holistic health education and to inform the development of world-leading advanced delivery products. THREE™ is a movement led by [Daniel Picou](https://threeinternational.com/en/our-team), Founder & CEO, that is changing lives around the world by delivering healthy options to PEOPLE, greater PURPOSE through our caring community, and a dynamic PLATFORM for entrepreneurship. Learn more at: [threeinternational.com](https://threeinternational.com/en/aboutus). - [![Learn more about THREE International](https://blog.threeinternational.com/hs-fs/hubfs/THREE-Blog-About-THREE-Video-Screenshot.jpg?width=1200&height=673&name=THREE-Blog-About-THREE-Video-Screenshot.jpg) ](https://threeinternational.com/en/aboutus)   Share: [facebook-f icon ](http://www.facebook.com/share.php?u=https://blog.threeinternational.com/en/dr.-dan-guest-appearance-on-the-optimal-protein-podcast-with-vanessa-spina) [Share this page on LinkedIn ](http://www.linkedin.com/shareArticle?mini=true&url=https://blog.threeinternational.com/en/dr.-dan-guest-appearance-on-the-optimal-protein-podcast-with-vanessa-spina) [Share this page on X ](https://twitter.com/intent/tweet?url=https://blog.threeinternational.com/en/dr.-dan-guest-appearance-on-the-optimal-protein-podcast-with-vanessa-spina) [Share this page on Pinterest ](http://pinterest.com/pin/create/link/?url=https://blog.threeinternational.com/en/dr.-dan-guest-appearance-on-the-optimal-protein-podcast-with-vanessa-spina) [Share this page via Email ](mailto:?body=https://blog.threeinternational.com/en/dr.-dan-guest-appearance-on-the-optimal-protein-podcast-with-vanessa-spina) ## Related posts [![Dr Dan Gubler explores the pacific northwest for hidden healthy molecules within the lush rainforest vegetation ](https://blog.threeinternational.com/hubfs/Explore-With-Dr-Dan-Episode-1-01.jpg) ](https://blog.threeinternational.com/en/discover-the-untapped-potential-of-the-pacific-northwest-with-dr-dan?hsLang=en) [Ingredients](https://blog.threeinternational.com/en/tag/ingredients) ### [Discover the Untapped Potential of the Pacific Northwest with Dr. Dan](https://blog.threeinternational.com/en/discover-the-untapped-potential-of-the-pacific-northwest-with-dr-dan?hsLang=en) [![Dr Dan Gubler Chief Scientist of THREE International on an Exploration for Bioavailability](https://blog.threeinternational.com/hubfs/Dr-Dan-Revolutionizing-Supplement.jpg) ](https://blog.threeinternational.com/en/revolutionizing-supplement-science-disover-biovailability-breakthroughs-with-dr-dan?hsLang=en) [Ingredients](https://blog.threeinternational.com/en/tag/ingredients) ### [Dr. Dan’s Breakthroughs at THREE](https://blog.threeinternational.com/en/revolutionizing-supplement-science-disover-biovailability-breakthroughs-with-dr-dan?hsLang=en) [![Dr Dan Gubler of THREE International walking through a barren desert in Death Valley](https://blog.threeinternational.com/hubfs/Explore-with-Dr-Dan-Ep-3_04.jpg) ](https://blog.threeinternational.com/en/exploring-the-hottest-place-on-earth-with-dr.-dan?hsLang=en) [Ingredients](https://blog.threeinternational.com/en/tag/ingredients) ### [Exploring the Hottest Place on Earth with Dr. Dan](https://blog.threeinternational.com/en/exploring-the-hottest-place-on-earth-with-dr.-dan?hsLang=en) ```json { "@context" : "https://schema.org", "@type" : "BlogPosting", "author" : { "@type" : "Person", "name" : "Three", "url" : "https://blog.threeinternational.com/en/author/three" }, "dateModified" : "2024-06-14T20:41:52.842Z", "datePublished" : "2024-06-14T20:26:55.000Z", "headline" : "Dr. Dan’s Guest Appearance on the Optimal Protein Podcast with Vanessa Spina", "image" : [ "https://blog.threeinternational.com/hubfs/Optimal-Protein-Podcast-Featured-Image-v4.jpg" ], "mainEntityOfPage" : { "@id" : "https://blog.threeinternational.com/en/dr.-dan-guest-appearance-on-the-optimal-protein-podcast-with-vanessa-spina", "@type" : "WebPage" }, "publisher" : { "@type" : "Organization", "logo" : { "@type" : "ImageObject", "url" : "https://blog.threeinternational.com/hubfs/ThreeLogoBlack.png" }, "name" : "THREE International" } } ``` ```json { "@context" : "http://schema.org", "@type" : "Article", "author" : { "@type" : "Person", "name" : [ "Three" ], "url" : "https://blog.threeinternational.com/en/author/three" }, "datePublished" : "2024-06-14T20:26:55+0000", "description" : "Dr. Dan Gubler was a guest on the Optimal Protein Podcast with Vanessa Spina to share insights on optimizing genes with ketosis and intermittent fasting", "headline" : "Dr. Dan’s Guest Appearance on the Optimal Protein Podcast with Vanessa Spina", "image" : "https://40664356.fs1.hubspotusercontent-na1.net/hubfs/40664356/Optimal-Protein-Podcast-Featured-Image-v4.jpg", "publisher" : { "@type" : "Organization", "logo" : { "@type" : "ImageObject", "url" : "" }, "name" : "THREE International" }, "url" : "https://blog.threeinternational.com/en/dr.-dan-guest-appearance-on-the-optimal-protein-podcast-with-vanessa-spina" } ```